Molecular Classification of Carcinoma of Unknown Primary

Grant number: 251654

Abstract

Carcinoma of unknown primary (CUP) is the fourth largest cause of cancer death. The condition has a particularly poor outlook, with a median survival of less than one year. Current methods for diagnosis of CUP include histopathology and sophisticated imaging. These are successful in approximately 40% of cases. Frequently the reason for the poor outcome in this disease is that the 60% of patients with CUP for whom no diagnosis is made do not benefit from chemotherapy specifically designed for a particular tumour origin. These patients receive a less effective, generic, chemotherapy. The aim of this project is to use microarrays to identify the gene expression profile in many known tumours to ..

View full description

Related publications (10)

Scholarly works icon

Rapid degranulation of NK cells following activation by HIV-specific antibodies

AW Chung, E Rollman, RJ Center, SJ Kent, I Stratov

2009-01-15

Ab-dependent cellular cytotoxicity (ADCC) Abs stimulate NK cell effector functions and play a role in protecting from and controll..

Scholarly works icon

Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs

E Rollman, RD Mason, J Lin, AG Brooks, SJ Kent

2008-12-01

Background: Live attenuated SIV vaccines are highly efficacious, but how they mediate protection is poorly understood. A feature o..

Scholarly works icon

Anti-SIV cytolytic molecules in pigtail macaques

E Rollman, SJ Turner, K Kedzierska, SJ Kent

2008-08-01

Release of granzymes and perforin from the cytolytic granules of SIV-specific CD8 T cells is a critically important effector mecha..

Scholarly works icon

Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques

R De Rose, CJ Batten, MZ Smith, CS Fernandez, V Peut, S Thomson, IA Ramshaw, BEH Coupar, DB Boyle, V Venturi, MP Davenport, SJ Kent

2007-01-01

Vaccination against AIDS is hampered by great diversity between human immunodeficiency virus (HIV) strains. Heterologous B-subtype..

Scholarly works icon

Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3

SJ Kent, CJ Dale, C Ranasinghe, I Stratov, R De Rose, S Chea, DC Montefiori, S Thomson, IA Ramshaw, BEH Coupar, DB Boyle, M Law, KM Wilson, AJ Ramsay

2005-10-10

Further advances are required in understanding protection from AIDS by T cell immunity across mucosal sites of virus transmission...

Scholarly works icon

Phenotypic and kinetic analysis of effective simian-human immunodeficiency virus-specific T cell responses in DNA- and fowlpox virus-vaccinated macaques

I Stratov, CJ Dale, SJ Kent

2005-07-05

Although T cell immunity is important in the control of HIV-1 infection, the characteristics of effective HIV-specific T cell resp..

Scholarly works icon

Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost

CS Fernandez, I Stratov, R De Rose, K Walsh, CJ Dale, MZ Smith, MB Agy, SL Hu, K Krebs, DI Watkins, DH O'Connor, MP Davenport, SJ Kent

2005-05-01

Escape from specific T-cell responses contributes to the progression of human immunodeficiency virus type 1 (HIV-1) infection. T-c..

Scholarly works icon

Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes

MZ Smith, CJ Dale, R De Rose, I Stratov, CS Fernandez, AG Brooks, J Weinfurter, K Krebs, C Riek, DI Watkins, DH O'Connor, SJ Kent

2005-01-01

Successful human immunodeficiency virus (HIV) vaccines will need to induce effective T-cell immunity. We studied immunodominant si..

Scholarly works icon

Granulocyte contamination dramatically inhibits spot formation in AIDS virus-specific ELISpot assays: Analysis and strategies to ameliorate

R De Rose, EL Taylor, MG Law, PH Van Der Meide, SJ Kent

2005-01-01

The interferon-γ (IFNγ) ELISpot assay has become the most critical tool for HIV vaccine evaluation. External factors affecting ELI..

Scholarly works icon

Reversion of immune escape HIV variants upon transmission: Insights into effective viral immunity

SJ Kent, CS Fernandez, CJ Dale, MP Davenport

2005-01-01

Many viruses that cause chronic viremic infections, such as human immunodeficiency virus type 1 (HIV-1), mutate extensively to avo..

University of Melbourne Researchers